Clinical Psychiatry News - Desyrel label warns of drug interactions
Sunday, January 4th, 2009 New labeling for Desyrel (trazodone hydrochloride) alerts health care professionals to potential drug interactions with ketoconazole, ritonavir, and indinavir.
Changes to the clinical pharmacology section of the label note that trazodone–indicated for the treatment of depression–is a substrate of the cytochrome P450 3A4 (CYP3A4) enzyme and that trazodone metabolism can be inhibited by the CYP3A4 inhibito…
