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Of 79 men in whom clinical and laboratory examinations revealed no organic cause for their impotence; 20 men received testosterone, 21 received trazodone, 20 underwent hypnosis and 18 served as placebo controls. They were assessed by interview 4, 6 and 8 weeks after starting treatment: the patient’s reports were verified by interviewing their partners. Placebo men had a 39% improvement in sexual function v. rates of improvement in the testosterone, trazodone and hypnosis groups of 60…

New labeling for Desyrel (trazodone hydrochloride) alerts health care professionals to potential drug interactions with ketoconazole, ritonavir, and indinavir.
Changes to the clinical pharmacology section of the label note that trazodone–indicated for the treatment of depression–is a substrate of the cytochrome P450 3A4 (CYP3A4) enzyme and that trazodone metabolism can be inhibited by the CYP3A4 inhibito…